Differential effects of high-fat diet on glucose tolerance, food intake, and glucocorticoid regulation in male C57BL/6J and BALB/cJ mice | Semantic Scholar (2024)

It is suggested that regulation of the daily rhythm of eating may underlie propensity to develop diet-induced obesity in male mice.

Obesity in Hi-ST mice indicates that dietary manipulation can influence insulin action independently of the level of adiposity and that the presence of specific ceramide species correlate with these differences.

Fat but not salt content in the diet is a determining factor in the regulation of FI and body weight, and glucose metabolism can be influenced by both the fat and salt content of the diet.

Comparing the effects of continuous-moderate vs. high-intensity interval aerobic training on cardiovascular and metabolic parameters in ovariectomized high-fat-fed mice showed that moderate-intensity continuous training was more effective in promoting cardiovascular benefits, while high- intensity intervalTraining was moreeffective in promoting metabolic benefits.

Investigating the liver lipid metabolism and anti-diabetic properties of PN in diet-induced obesity mice suggested that PN provided the health benefit to slow the progression of NAFLD and T2DM in obese and pre-di diabetic conditions.

Observed observations add to a growing body of evidence reporting suppressive effects of high-energy foods on stress-associated glucocorticoids reactivity and are consistent with the comfort food hypothesis, where people are seen as motivated to eat palatable foods to alleviate the detrimental repercussions of stressor exposure.

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It is concluded that the high-fat diet-fed C57BL/6J mouse model is a robust model for IGT and early type 2 diabetes, which may be used for studies on pathophysiology and development of new treatment.

Findings indicate that most mouse strains develop metabolic defects on an HFD, however, there are inherent differences between strains, and thus the genetic background needs to be considered carefully in metabolic studies.

It is suggested that fasting per se has a significant effect on hepatic lipid accumulation in mouse strains and that SREBP1 might play a role in this fasting effect.

The characteristics of obesity induced by HFD feeding were influenced by the sex, strain and age of mice, and sex steroid hormones, hepatic lipid metabolism and systemic metabolism might be involved in these factors.

The experiments show that glucocorticoids provoke dose-related increases in total caloric intake that persist for days and weeks; the results suggest that some human obesities may result from elevated glucoc Corticosterone and insulin increasing the proportional intake of high density calories.

The fatty accumulation observed in BALB/c mice may be caused, at least in part, by up-regulation of fatty acid uptake and biosynthesis, and Cd36, Acaca, Acly and Fasn may be involved in these metabolic processes.

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