Plaque Psoriasis Dosing | COSENTYX® (secukinumab) (2024)

Do not use COSENTYX if you have had a severe allergic reaction to secukinumab or any of the other ingredients in COSENTYX. See the Medication Guide for a complete list of ingredients.

What is the most important information I should know about COSENTYX?

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as:

Infections

COSENTYX may lower the ability of your immune system to fight infections and may increase your risk of infections. Some people have died from these infections.

Before starting COSENTYX, tell your doctor if you:

  • are being treated for an infection

  • have an infection that does not go away or that keeps coming back

  • have TB or have been in close contact with someone with TB

  • think you have an infection or have symptoms of an infection such as: fevers, sweats, or chills; muscle aches; cough; shortness of breath; blood in your phlegm; weight loss; warm, red, or painful skin or sores on your body; diarrhea or stomach pain; burning when you urinate or urinate more often than normal

After starting COSENTYX, call your doctor right away if you have any signs of infection listed above. Do not use COSENTYX if you have any signs of infection unless you are instructed to by your doctor.

What are the possible side effects of COSENTYX?

COSENTYX may cause serious side effects, including:

Serious allergic reactions

Serious allergic reactions can occur. Get emergency medical help right away if you get any of the following symptoms: feeling faint; swelling of your face, eyelids, lips, mouth, tongue, or throat; trouble breathing or throat tightness; chest tightness; skin rash or hives (red, itchy bumps).

If you have a severe allergic reaction, do not give another injection of COSENTYX.

Inflammatory bowel disease

New cases of inflammatory bowel disease or "flare-ups" can happen with COSENTYX, and can sometimes be serious. If you have inflammatory bowel disease (ulcerative colitis or Crohn's disease), tell your doctor if you have worsening disease symptoms during treatment with COSENTYX or develop new symptoms of stomach pain or diarrhea.

Severe skin reactions that look like eczema can happen during treatment with COSENTYX from days to months after your first dose and can sometimes lead to hospitalization. Your doctor may temporarily stop treatment with COSENTYX if you develop severe skin reactions. Tell your doctor if you have any of the following signs or symptoms:redness or rash; itching; small bumps or patches; your skin is dry or feels like leather; blisters on the hands or feet that ooze or become crusty or skin peeling.

The most common side effects of COSENTYX include: cold symptoms, diarrhea, and upper respiratory tract infections.

These are not all of the possible side effects of COSENTYX. Call your doctor for medical advice about side effects.

Before using COSENTYX, tell your doctor if you:

  • have any of the conditions or symptoms listed abovefor infections.

  • have inflammatory bowel disease (Crohn's disease or ulcerative colitis).

  • are allergic to latex. The needle cap on the COSENTYX Sensoready® pen, and 150 mg/mL and75 mg/0.5 mL prefilled syringes contains latex.

  • have recently received or are scheduled to receive an immunization (vaccine). People who take COSENTYX should not receive live vaccines. Children should be brought up to date with all vaccines before starting COSENTYX.

  • have any other medical conditions and all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. Keep a list of your medicines to show your healthcare provider and pharmacist when you get a new medicine.

  • are pregnant or plan to become pregnant. It is not known if COSENTYX can harm your unborn baby. You and your doctor should decide if you will use COSENTYX.

  • are breastfeeding or plan to breastfeed. It is not known if COSENTYX passes into your breast milk.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch ↗, or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide.

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Plaque Psoriasis Dosing | COSENTYX® (secukinumab) (2024)

FAQs

Plaque Psoriasis Dosing | COSENTYX® (secukinumab)? ›

The recommended dose of COSENTYX® (secukinumab) for moderate-severe plaque psoriasis is 300 mg. To start, your doctor will prescribe 5 weekly loading doses.

How much COSENTYX should I take for plaque psoriasis? ›

2.3 Recommended Dosage in Plaque Psoriasis

The recommended dosage in adults with PsO is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter. Each 300 mg dosage is given as one subcutaneous injection of 300 mg or as two subcutaneous injections of 150 mg.

What is the initial dosing for secukinumab? ›

Secukinumab
  • Adult: 300 mg every week for 5 doses, followed by 300 mg every month. ...
  • Adult: 150 mg every week for 5 doses, followed by 150 mg every month, may increase to 300 mg if response is inadequate. ...
  • Adult: 150 mg once weekly for 5 weeks, then once monthly thereafter.

What is the success rate of secukinumab? ›

Real-life studies have highlighted the good efficacy and safety of the drug for up to 2 years of treatment, with conflicting results on drug survival (DS), ranging from 74.3% to 59% [13,14,15,16,17,18,19,20,21,22].

How long does it take for COSENTYX to work for plaque psoriasis? ›

People taking Cosentyx reported that their symptoms eased within 12 weeks of using the drug to treat plaque psoriasis. People using Cosentyx to treat PsA reported that their symptoms eased after 16 weeks of treatment. Some people receiving Cosentyx reported symptom relief in as few as 3 weeks.

What is the best medicine for severe plaque psoriasis? ›

Several of these drugs are approved for the treatment of moderate to severe psoriasis in people who haven't responded to first line therapies. Options include etanercept (Enbrel), infliximab (Remicade), adalimumab (Humira), ustekinumab (Stelara), risankizumab-rzaa (Skyrizi) and ixekizumab (Taltz).

What is the safest biologic for plaque psoriasis? ›

Cimzia, Enbrel, Humira, and Remicade are shown to be safe and effective when taken with methotrexate. Talk to your health care provider about whether using any other treatments with a biologic is right for you.

How quickly does secukinumab work? ›

Secukinumab works by blocking the effects of this protein, to reduce inflammation and the problems it can cause, such as joint pain and stiffness. It's a long-term treatment. Depending on your condition, it may take between three weeks and a year of taking secukinumab before you start to see the benefits.

Does secukinumab cause weight gain? ›

Secukinumab does not cause weight gain. There is no proof that this drug increases belly fat. However, there can be weight loss in some cases because of some of the side effects, such as diarrhoea or infections.

Is etanercept better than secukinumab for psoriasis? ›

Etanercept has an average rating of 7.8 out of 10 from a total of 321 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 13% reported a negative effect. Secukinumab has an average rating of 6.3 out of 10 from a total of 244 ratings on Drugs.com.

Is cosentyx safer than humira? ›

And Cosentyx causes fewer side effects, particularly serious side effects, than Humira. But it's also important to consider your health history. For example, if you have inflammatory bowel disease, taking Cosentyx could make it worse. On the other hand, Humira is approved to treat this condition.

Is Otezla better than Cosentyx? ›

Cosentyx has an average rating of 6.3 out of 10 from a total of 234 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 32% reported a negative effect. Otezla has an average rating of 5.2 out of 10 from a total of 438 ratings on Drugs.com.

Does secukinumab affect the liver? ›

Body weight and uric acid levels tended to decrease over 52 weeks with secukinumab. Secukinumab showed a neutral effect on fasting plasma glucose, lipid parameters and liver enzymes.

Why did my plaque psoriasis go away? ›

Even without treatment, psoriasis may disappear. Spontaneous remission, or remission that occurs without treatment, is also possible. In that case, it's likely your immune system turned off its attack on your body. This allows the symptoms to fade.

What is the fastest way to cure plaque psoriasis? ›

There's no cure for psoriasis. But treatment can help you feel better. You may need topical, oral, or body-wide (systemic) treatments. Even if you have severe psoriasis, there are good ways to manage your flare-ups.

Does COSENTYX help with plaque psoriasis? ›

COSENTYX treats both plaque psoriasis and psoriatic arthritis, including troublesome areas like the scalp and nails. Learn more about the connection between plaque psoriasis and psoriatic arthritis.

Can you take too much COSENTYX? ›

The maximum dosage of Cosentyx is 300 mg taken every four weeks. Taking too much of this medication may result in severe immunosuppression. Only take the dose of Cosentyx that is recommended by your healthcare provider.

How do you treat thick plaque psoriasis? ›

In more severe or widespread cases of plaque psoriasis, your healthcare provider may prescribe:
  1. Medicine injections. Your healthcare provider will use a thin needle to inject medicine into your skin or a vein in your arm. ...
  2. Oral medicines. Oral medicines are pills or tablets that you swallow with water. ...
  3. Phototherapy.

How long does plaque psoriasis take to clear up? ›

You may notice improvement with topical products as soon as 1 to 2 weeks . You may see less psoriasis in 4 to 6 weeks. With stronger medications for moderate or severe psoriasis, like the immune suppressant methotrexate, it may take up to 6 months for you to reach complete clearing.

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